Medicine and process of preparing same



Patented Dec. 11, 1934 1,983,954

UNITED STATES PATENT OFFICE Guy 0. Taylor, Decatur, Ill., assignor to Flint Eaton and Company, Decatur, 311., a corporation of Illinois No Drawing. Application May 20, 1933, Serial No. 672,082

3 Claims. (Cl- 167-57) This invention relates to a preparation whichis that the reaction will take place and the gas will highly effective as a means of ingesting calcium be'liberated. into the human body, in the practice oi calcium The advantage of the present invention is, (1), therapy. 7 that it affords a pleasant and acceptable means Investigators have pointed out hat calcium of orally administering calcium to the human 5 therapy has been seriously hindered by the untobody, (2) the mixture comprises a minimum perward physiological and pharmacological propcentage of efiervescent chemicals, and (3), it is erties of almost all calcium salts. That is, many possible by the use of the mixture to assure withare hygroscopic, practically all are nausegtingly in quite accurate limits that the minimum resalty-bitter to the taste and many are not well quired d o Calcium g on te w ll be made 10 borne by the gastro-intestinal tract. available to the user.

One of the difiiculties encountered in calcium In further explanation of the a v ytherapy is the danger of acidosis and nephritis five grains three times a day for adults and resulting from the cumulative effect of large doses thirty grains three times a day for h ldren has of calcium chloride as well as lesser objections of been considered t p oper quantity, and the 15 tissue irritability and nausea. Calcium lactate p sent preparation enables the user to p p is usually not well tolerated. this dosage without fear of using either too much A change for the better as regards calcium or O l le. therapy marked the introduction a-iew years ago n car ying out the invention, 1 take by oi a heretofore untried salt of calcium, namely weight n i le nic a i for mnp e I me 20 calcium gluconate. This preparation, a calcium fer citric acid but maleic, tartaric and the like salt of gluconic acid, is an oxidation product of acids y be satisfactorily mpl y d. The quanglucose and has the following properties: It is 01 the'edime Organic acid is 3 t y tasteless, soluble in water to the extent of 3% at P room temperature and up to 20 or at higher I take l dry Sodium bicarbonate or a simi- 25 temperatures. It contains approximately 9% p und which hydroly s n Water or which calcium and 37% of nm acid it some is susceptibleto reaction with the acid to produce water of crystallization. Physiologically and Carbon dioxide- The amount of d y Sod um bi-- pharmacologically, it is equivalent of CaCla in Carbonate employed is u y tw nty-five parts.

30 equimolecular concentrations, and can be adminwith respect to the two members just d ib d, 30 istered either Orally or by subcutaneous, 1m it is desirable that the organic edible acid be muscular or intravenous injection, being usually Stronger than c bonic acid, so that when these 11 borne by 11 fgur routes two 'efiervescent members are in contact in water, The present invention is an r ti i the reaction will proceed with the liberation of ture in dry state, readily soluble in water, has a 09113011 dioxlde- 35 pleasant taste and is characterized by having the I Preferably oy t dry calcium siuconate calcium gluconate constituting substantially 50% in the form of an impalpable p der and to the of the njxturg In t manner, 1 am able t amount of substantially forty-five parts of the avoid the use of enormous quantities of eiferunfused Chemicals; The u glu onate is 40 vescent chemicals and at the same time assure Present ill Substantial amount to be p u 40 that optimum amounts of the calcium will be oolly effective for oeloium ap 1- up t availabla j 50% of the dry mass. Preferably the calcium The product of the present invention, 1. e., an Eluconate is present in amount eater than the unreactive mixture in dry state will comprise an amount o t er t e edible acid or the amount edible acid, such as citric acid, a member capable of the sodium bicarbonate. 45

of reacting therewith to form CO2, in the presence It is t be u st d at in v n th parts of water such as sodium bicarbonate, and calcium a v m n d, y ay be vari d more or gluconate. It is prepared as a dry mixture and less. the a ple given being a p e ab on itwill be observed that the acid and the carbonate and consisting of a small mass of the effervescent react to produce CO2, in the presence of water, in chemicals and a large mass of the calcium gluwhich surcharged liquid, the gluconate is readily conate. In other words, the effervescent chemisoluble. Various edible acids may be employed cals in combined parts by weight are substanas well as ingredients capable of reacting there tially equal to that of the mass of calcium gluwith to produce CO2. Of course, the organic conate. 5 acid should be stronger than carbonic acid, so The process proceeds by adding to the dry calcium gluconate substantially five ounces of distilled water to each ninety ounces of dry calcium gluconate when the humidity of the mixing room is indicated by a difference of eight degrees centigrade appearing on the dry and wet bulb thermometer. The nature of calcium gluconate is such that it absorbs this moisture completely and the addition of such moisture does not set up a reaction between the alkali material and the organic acid when these materials are mixed and triturated. The necessary amount of distilled water, as stated, is added to the dry calcium gluconate and thoroughly -distributed. I also add to each ninety ounces of dry calcium gluconate three ounces of alcohol in which is dissolved an *aromatic substance (about 3 drams) for example,

oil of lemon which is thoroughly distributed by the alcohol. H

Thereafter, the dry sodium bicarbonate is added and the two materials are thoroughly mixed, for example, by screening. Then the organic acid is added to the mixture and completely incorporated while all three-ingredients are in a dry state.

The addition of the moisture and the aromatic solution to the calcium gluconate must be undertaken with care so as not to set up any reactions between the edible acid and the bicarbonate when the mixture is produced. The treatment may proceed in other ways, it being, however, the purpose of this step to prepare the mass so that it may subsequently be fused.

The substantially dry mixture as prepared is now fused in a suitable vessel by application of heat. The alcohol greatly aids the fusion of the chemicals I have used, for example, a water bath with'good results. Observations are carefully taken and when the mixture has assumed the proper consistency the heating is discontinued and the mass in fused condition is broken into granules by being forced "through a #6 screen or one of any suitable mesh. The granular material screened in this manner is now dried thoroughly. It is preferable to use low' temperature driers as by circulating air without application of heat. H 1

There is comparatively little loss of carbon dioxide when the material is prepared by this method. Examination of the material discloses that the mixture is unreactive, and it will analyze approximately fifty per cent calcium gluconate, the gain being due to a loss of water of crystal lization in the organic acid. The resultant mixture, therefore, contains the effervescent chemicals in substantially fifty percent and the 'calcium .gluconate in equal percentage. In this manner, it is unnecessary to utilize 'la'rge quantities of eiiervescent chemicals in order to obtain the required amount of calcium gluconate for the dosage. In fact, the calcium of gluconate is fifty per cent of the mass as above stated.

The preparation is now packed in air-tight sealed containers and is ready for distribution.

In view of the fact that the percentage of calcium gluconatein the product is determined, a user by adding the directed quantity to water will be assured of having in solution the required dosage of calcium gluconate. This is important quantity of calcium gluconate for a dosage, it is to be understood that by the present invention the percentage of calcium gluconate present in the mixture can be varied within wide limits up to and including this maximum dosage.

The user will take a teaspoon of the material or a partially filled teaspoon, as the case may be, and add it to either cold or warm water. The acid and bicarbonate will react and the 'gluconate is quite soluble in the freshly surcharged carbonic water. It is preferable to use warm water, the solution being more rapid, but equally good results are obtained with cold water.

It will be observed. therefore, that the preparation is an unreactive mixture in dry state comprising ingredients which however will react in the presence of water to produce ready solution of the calcium gluconate therein and that the ingestion of calcium will take place effectively and pleasantly and in the proper amount, without recourse to tremendous amounts of eifer- I vescent chemicals. .1 claim; 7 w

1. A dry, fused mixture in granular form for oral administration and unreactive in the absence of water comprising calcium gluconate, an edible organic acid and a member of the order 'of sodium bicarbonate capable of reacting in the presence of water with said organic acid to liberate carbon-dioxide and surcharge the waten'the calcium. gluconate being present in the dry mass in percentage greater than the other members.

2. Adry, fused mixture in granular form for oral administration and unreactive in the absence of water comprising calcium gluconate, an

edible organic acid and a member of the order of sodium bicarbonate capable of reacting in the I reactive in the absence of water of calcium gluconate, an edible acid and a member' capable of reacting therewith in the presence of water'to liberate CO2, which comprises adding to dry' calcium gluconate and distributing therein, water in amount to promote fusion of the three ingredients but insuiilcient to produce reaction of the two CO2 producing members when the water is distributed in and absorbed by the calcium gluconate and when the two CO2 producing members are mixed with the calcium gluconate, thereafter mixing with the calcium gluconate having the absorbed water, the edible acid and a member of the order of sodium bicarbonate, both in dry state, fusing the mixture, and particulating the fused mixture to granular form.

. GUY C. TAYLOR..- 

